Bioactive Small Molecules

1-Oxa-3,8-diazaspiro[4.5]decan-2-one

1-Oxa-3,8-diazaspiro[4.5]decan-2-one (click to show)

1-Oxa-3,8-diazaspiro[4.5]decan-2-one (click to hide)

Title:

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.

Reference:

ACS Med Chem Lett. 2014 Jan 2;5(4):340-5. eCollection 2014.

Authors:

Methot JL, Hoffman DM, Witter DJ, Stanton MG, Harrington P, Hamblett C, Siliphaivanh P, Wilson K, Hubbs J, Heidebrecht R, Kral AM, Ozerova N, Fleming JC, Wang H, Szewczak AA, Middleton RE, Hughes B, Cruz JC, Haines BB, Chenard M, Kenific CM, Harsch A, Secrist JP, Miller TA.

Compounds:

1-Oxa-3,8-diazaspiro[4.5]decan-2-one (4037223)