Bioactive Small Molecules

1-(3-((cyclopentylamino)methyl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol (1)

1-(3-((cyclopentylamino)methyl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol (1) (click to show)

1-(3-((cyclopentylamino)methyl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol (1) (click to hide)

Title:

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

Reference:

ACS Med Chem Lett. 2015 Dec 2;7(2):162-6. eCollection 2016.

Authors:

Duncan KW, Rioux N, Boriack-Sjodin PA, Munchhof MJ, Reiter LA, Majer CR, Jin L, Johnston LD, Chan-Penebre E, Kuplast KG, Porter Scott M, Pollock RM, Waters NJ, Smith JJ, Moyer MP, Copeland RA, Chesworth R.

Compounds:

1-(3-((cyclopentylamino)methyl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol (1) (39852262)