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From Hit to Lead at the Speed of Light
Cat. No. BIOTK-ALK
ALK, Anaplastic lymphoma kinase is an orphan receptor protein-tyrosine kinase that belongs to the insulin receptor super family. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Cat. No. BIOTK-EGFR
EGFR, Epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. EGFR is implicated in proliferation of tumor cells and enhanced tumor cell survival. Mutations affecting EGFR expression or activity could result in lung cancer.
Cat. No. BIOTK-EphA2
EphA2, EPH receptor A2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.
Cat. No. BIOTK-FAK
FAK, Focal Adhesion Kinase is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. FAK activation may play an important early role in cell growth and intracellular signal transduction pathways.
Cat. No. BIOTK-FGFR1
FGFR1, Fibroblast growth factor receptor 1 is the receptor of the FGFR tyrosine kinase family. FGFs are potent physiological regulators, influencing mitogenesis.
Cat. No. BIOTK-FGFR2
FGFR2, Fibroblast growth factor receptor 2 is the receptor of the FGFR tyrosine kinase family. FGFR2 is expressed in developing human tissues, including brain, skin, lungs and kidney, and it has been implicated in formation of tumors.
Cat. No. BIOTK-FLT1
FLT1, Fms-related tyrosine kinase 1 belongs to the VEGFR family of kinases. FLT1 plays a key role in angiogenesis and many other pathological and physiological processes, such as tumor progression, etc.
Cat. No. BIOTK-IGFR1
IFG1R, Insulin-like Growth Factor 1 (IGF-1) Receptor is a trans-membrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. IGF1R plays an important role in cell growth and transformation events.
Cat. No. BIOTK-LYNa
LYNa, is a member of the Src family of non-receptor associated protein tyrosine kinases. The Src related protein kinases are known to control a wide variety of cellular processes.
Cat. No. BIOTK-SYK
SYK, Spleen tyrosine kinase is a member of the Syk family of non-receptor cytoplasmic tyrosine kinases. SYK is prolific in its involvement in cell signaling cascades.